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    • #18304
      whbio
      Participant

      Colorectal cancer (CRC) is one of the most popular and lethal cancers in America. It is caused by genetic mutations and epigenetic changes. For the first time, MUSC researchers have found that KLF12 promotes CRC tumor growth by directly activating early growth response protein 1 (EGR1), and both KLF12 and EGR1 levels contribute to the bad clinical outcome in CRC patients.

    • #116063
      claudepa
      Participant

      Cancer has been sometimes described as a disease of transcription factors. If you inhibit KLF12 in grafted tumors does the tumor shrinks ?

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