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      I have a question about chromosomal instability and aneuploidy which I was hoping someone could answer. I am interested in ranking ovarian cancer cell lines based on their chromosomal instability (i.e. high or low). To do this, I’ve obtained the average ploidy value for the cell lines of interest from the Sanger Cosmic Cell Line database. I’d like to essentially group the cell lines based on high or low chromosomal instability as indicated by their average ploidy value.

      My question is this: what ‘threshold’ ploidy value would be considered aneuploidy? For example, I know that a value of 2 means diploid, but is a value of 2.3, 2.4 or even 2.6 considered aneuploid? Does anyone of links to relevant/useful papers that might define such a threshold?


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