Your question has to be a little bit specific because of the following reason :
(Mostly polyploidy is seen in plants and in cells of muscle tissues of some animals)
The presence of more than two alleles in an individual and the complexity of inheritance pattern, pose several problems when estimating allele frequencies in polyploids. Firstly, in polyploids even with codominant markers, the dosage of alleles cannot be deduced with certainty for some marker phenotypes, since current technology does not allow for estimating allele dosage from observed band intensities. As an example, for a tetraploid with four distinct codominant alleles showing polysomic inheritance 35 genotypes are possible but these fall under only 15 marker phenotypes. Of these marker phenotypes, genotypes can be deduced fully only in case of monoallele and quadriallele classes. Consequently, polypoid allele frequencies cannot be calculated directly. As second complication arises if ‘null’ alleles are truly present in a population. Their presence may not be obvious: unlike the case of diploids, null individuals extremely will be rare, even when the null allele frequency is moderately high.
