August 13, 2017 at 4:15 pm #18438biostar2Participant
We’d like to announce the availability of a bioinformatics training resource: The Biostar Handbook.
The Biostar Handbook introduces readers to bioinformatics, the scientific discipline at the intersection of biology, computer science, and statistical data analytics that is dedicated to the digital processing of genomic information:
The contents of this book have provided the analytical foundation to hundreds of students, many of whom have become full-time bioinformaticians and work at the most innovative companies in the world.
December 18, 2018 at 5:43 am #116403rahilsaxenaParticipant
Epitope, also called antigenic determinant, portion of a foreign protein, or antigen, that is capable of stimulating an immune response. An epitope is the part of the antigen that binds to a specific antigen receptor on the surface of a B cell. Binding between the receptor and epitope occurs only if their structures are complementary. If they are, epitope and receptor fit together like two pieces of a puzzle, an event that is necessary to activate B-cell production of antibodies. The antibodies produced by B cells are targeted specifically to the epitopes that bind to the cells’ antigen receptors. Thus, the epitope also is the region of the antigen that is recognized by specific antibodies, which bind to and remove the antigen from the body.
Many antigens have a variety of distinct epitopes on their surfaces. Each epitope is capable of reacting with a different B cell antigen receptor. In addition, the blood serum of an immunized person or animal normally contains a mixture of antibodies, all capable of combining with the same antigen but with different epitopes that appear on the surface of the antigen. Furthermore, antibodies that bind to the same epitope often have different abilities to bind to that epitope.
It is possible for two or more different antigens to have an epitope in common. In these cases, antibodies targeted to one antigen are able to react with all other antigens carrying the same epitope. Such antigens are known as cross-reacting antigens.
January 23, 2019 at 9:09 am #116407KikoGarciaParticipant
Next-generation sequencing has fundamentally revolutionized biological and medical sciences. A NGS/microarray data analysis project requires careful planning, seasoned methodology, and concise reporting. CD genomics is an expert company offering comprehensive bioinformatics solutions in all aspects of NGS and microarray. We provide data analysis service for data generated by a wide range of sequencing/microarray platforms. We use the cutting-edge bioinformatics algorithms and pipeline, and provide you with high-quality and ready-for-publication figures.
May 27, 2019 at 8:32 am #116425stephannieParticipant
Yes, I agree. NGS has really made the whole process so easy. I mean can you imagine having this technology for coding the human genome 29 years ago? It would have been so easy with the NGS software back then. There are so many applications of NGS where you can increase the sensitivity of sequencing down to 1% and produce more data in comparison to Sanger’s sequencing method. I have been working with a company called ‘Basepair’ that runs all these analysis to give you a report in a couple of days! Blows my mind with the kind of technology we have today. And the amount of accuracy and the various inferences that can be drawn from these reports could really change the way we look at diseases and mutations.
- This reply was modified 3 months, 3 weeks ago by Mark.
May 14, 2020 at 12:37 pm #117085MartyParticipant
Thanks for share!
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