[noy k]

how do we know a blast result is significant without relying on the e-value alone?

[fcs]

You can also look at the score which gives an indication of how good an alignment is:

http://www.ncbi.nlm.nih.gov/bookshelf/b … &part=ch16

[JackBean]

the e-value tells you, whether is it significant, why then look to something else? 🙄
score tells you, whether is it good alignment

[lishenghui]

the e-value and the score are entirely positive correlation, and i’m thinking the SCORE is more useful for evaluating a alignment: the e-value 1e-49 and 1e-51 are in the same significant, but the corresponded score 780 and 810 (approximately) are in the difference about 4%……..

[JackBean]

as I said above, the score tells you only how good is the alignment. But if you had some short sequence, it may have high score, but be less significant, then worst alignment, yet through longer sequence

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