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    • #16239
      studentbio
      Participant

      Hello, I am new to this forum as well to bioinformatics, however I have this project to do and I am completley blank… I am asking for help/advice from any kind people who know more than me about that subject.

      My project objective is to find out whether cytoplasmic loops of ‘7-transmembrane helix’ receptor proteins show structural homology/conserved features. I have chosen Class C (or 3) Metabotropic glutamate receptors to work on, I know roughly what genes encode different types of that receptor family proteins but I DO NOT know how to isolate sequences of cytoplasmic loops.

      Is there any way I can find this from entire sequence of the protein gene? OR there is some other ways?

      Please help.

      Thank you for all replies 😉

    • #110465
      JackBean
      Participant

      You need to determine, which segments are membrane-spanning helices. The rest are the extra-membranous loops. What I remember about 7TM proteins, one of them should be considerably longer and that’s the one you are looking for 😉

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