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    • #18285
      233
      Participant

      there are two endocytic pathways: clathrin dependent and clathrin independent.
      My question is: is there an example of clathrin-independent endocytosis in animal cells? 🙂

    • #116051
      claudepa
      Participant

      The figure 6 of this review article indicates that aptamer conjugates can follow the clathrin independent pathway. However I do not know the precise references on this point: E.W. Orawa et al. Biochemica et Biophysica Acta (2010) 1798, 2190-220

    • #116054
      233
      Participant

      thanks claudepa, i found a review article which gives an example of it.
      "some of best evidence for clathrin- and caveolin-independent endocytosis comes from studies on glycosylphosphatidylinositol(GPI)-anchored proteins" Molecular mechanisms of clathrin-independent
      endocytosis Carsten G. Hansen and Benjamin J. Nichols*

      (GPI)-anchored proteins are eukariotyc proteins which have a lots of biological functions( table 2 of The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins †
      Margot G. Paulick ‡ and Carolyn R. Bertozzi.)
      defect in this protein may lead rare diseases such as the destruction of red blood cells (Paroxysmal nocturnal hemoglobinuria)

    • #116137
      leesajohnson
      Participant

      Endocytosis and its counterpart, exocytose, are used by all cells because most chemical substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane by passive means. Endocytosis includes pinocytosis (cell drinking) and phagocytosed (cell eating).Phagocytises is a type of endocytosis in which white blood cells, specifically macrophages & neutrophils, engulf & digest bacteria as part of the body’s response to infection. Examples of Endocytosis:-Phagocytises of bacteria by Macrophages.
      Clathrin-mediated endocytosis:– Clathrin is a cytosolic protein which forms the coat over the molecules such as low-density lipids, transferring, growth factors and antibodies.

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