Fevers

[IneptStudent]

Hmmm… I use to be able to remeber this term but I can’t quite remember what the temperature elevating protein released by WBCs is named…Anybody have any answers or guesses?

[mith]

pyrogen?

[2810712]

i think its pyrogen.
by the way if mods permit, in the same thread, i want to know how do pyrogens help us…
is it like- stimulus[=?]—–>WBCs—–>pyrogens——>higher temp.–
—–> more K.E. …high reaction rate[= higher chances of collission of WBCs/Abs or other immunoproteins with the pathogen]——>higher chances killing or blocking certain pathogen.

If this is the mechanism, then, this improvement in the chances of killing due to pyrogenesis occurs for every pathogen irrespective of stimulator pathogen but is magnitudally different for different pathogens.

hrushikesh

[IneptStudent]

alright… thank you very much

[Dr.Stein]

So, it seems that I came very late 😛 Well, no question anymore? Problem is solved, case is closed 🙂

[2810712]

Hey Dr. please help me too… or should i start a new thread in the hope that somebody replies…

Thanks.

hrushikesh

[Dr.Stein]

Of course I will help you if I could, but what’s your question now?

Naaaah, don’t open a new thread except you have a new topic please. If your question is still in this topic, fevers, then let’s discuss just in here 🙂

[victor]

Pyrogens? not IL-2…. 😕
antigens – APCs (granulocytes and macrophages) – Th1 – IL-2 – increasing hypothalamus thermostate – B-cell proliferation and plasma cell differentiation – activated Tc….

[2810712]

I’ve explained my q –

i want to know how do pyrogens help us…
is it like- stimulus[=?]—–>WBCs—–>pyrogens——>higher temp.–
—–> more K.E. …high reaction rate[= higher chances of collission of WBCs/Abs or other immunoproteins with the pathogen]——>higher chances killing or blocking certain pathogen.
If this is the mechanism, then, this improvement in the chances of killing due to pyrogenesis occurs for every pathogen irrespective of stimulator pathogen but is magnitudally different for different pathogens.

Shrei

[victor]

hey, wanna ask…is Interleukin-2 one of the pyrogen member??

[Dr.Stein]

IL-2 is a cytokine, a T-cell growth factor.

Some examples of pyrogen are IL-1-alpha, IL-1-beta, IL-6, TNF family; all are cytokines produced by macrophage.

[victor]

But IL-2 is secreted by macrophage to affect hipothalamus and increase the body’s temperature isn’t it?

[2810712]

In what way temp increase help us in offence or deffence…

Shrei

[victor]

Increased temperature above normal will help specific immune system (B-cell and T-cell) proliferate and differentiate faster…(one beneficial side).
But, if the temperature is a way toooooooooo high, then it could be a tissue damage for the ill people…(one bad side).

[MrMistery]

also inhibits proliferation of bacteria

[Dr.Stein]

quote victor:

But IL-2 is secreted by macrophage to affect hipothalamus and increase the body’s temperature isn’t it?

Yes because hipothalamus is a centre of temperature regulation 🙂

The increased temperature or fever means to suppress the proliferation of pathogens (physical process to maintain homeostasis). When we have excessive pathogens, higher temperature we have. The proliferation of lymphocytes is due to the proliferation rate of pathogens and/or their infection rate.

[2810712]

Kindly explain a bit more i think i didn’t get it…:oops:

Shrei

[Dr.Stein]

Which part do you still get no point? Try to conclude this and we will check yours 🙂

[victor]

Ups..sorry..it’s not IL-2 but IL-1..:oops:

[Dr.Stein]

Aha! 😉

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