Fevers

Participant

i think its pyrogen.
by the way if mods permit, in the same thread, i want to know how do pyrogens help us…
is it like- stimulus[=?]—–>WBCs—–>pyrogens——>higher temp.–
—–> more K.E. …high reaction rate[= higher chances of collission of WBCs/Abs or other immunoproteins with the pathogen]——>higher chances killing or blocking certain pathogen.

If this is the mechanism, then, this improvement in the chances of killing due to pyrogenesis occurs for every pathogen irrespective of stimulator pathogen but is magnitudally different for different pathogens.

hrushikesh

January 6, 2006 at 10:03 pm #36398

IneptStudent

Participant

alright… thank you very much

January 7, 2006 at 8:03 am #36419

Participant

So, it seems that I came very late 😛 Well, no question anymore? Problem is solved, case is closed 🙂

January 7, 2006 at 9:32 am #36441

Participant

Hey Dr. please help me too… or should i start a new thread in the hope that somebody replies…

Thanks.

hrushikesh

January 7, 2006 at 9:41 am #36443

Participant

Of course I will help you if I could, but what’s your question now?

Naaaah, don’t open a new thread except you have a new topic please. If your question is still in this topic, fevers, then let’s discuss just in here 🙂

January 7, 2006 at 1:20 pm #36468

Participant

Pyrogens? not IL-2…. 😕
antigens – APCs (granulocytes and macrophages) – Th1 – IL-2 – increasing hypothalamus thermostate – B-cell proliferation and plasma cell differentiation – activated Tc….

January 8, 2006 at 4:12 am #36537

Participant

I’ve explained my q –

i want to know how do pyrogens help us…
is it like- stimulus[=?]—–>WBCs—–>pyrogens——>higher temp.–
—–> more K.E. …high reaction rate[= higher chances of collission of WBCs/Abs or other immunoproteins with the pathogen]——>higher chances killing or blocking certain pathogen.
If this is the mechanism, then, this improvement in the chances of killing due to pyrogenesis occurs for every pathogen irrespective of stimulator pathogen but is magnitudally different for different pathogens.

Shrei

January 8, 2006 at 12:45 pm #36573

Participant

hey, wanna ask…is Interleukin-2 one of the pyrogen member??

January 9, 2006 at 8:48 am #36623

Participant

IL-2 is a cytokine, a T-cell growth factor.

Some examples of pyrogen are IL-1-alpha, IL-1-beta, IL-6, TNF family; all are cytokines produced by macrophage.

January 10, 2006 at 12:44 pm #36744

Participant

But IL-2 is secreted by macrophage to affect hipothalamus and increase the body’s temperature isn’t it?

January 10, 2006 at 12:51 pm #36746

Participant

In what way temp increase help us in offence or deffence…

Shrei

January 10, 2006 at 12:56 pm #36749

Participant

Increased temperature above normal will help specific immune system (B-cell and T-cell) proliferate and differentiate faster…(one beneficial side).
But, if the temperature is a way toooooooooo high, then it could be a tissue damage for the ill people…(one bad side).

January 10, 2006 at 7:48 pm #36780

MrMistery

Participant

also inhibits proliferation of bacteria

January 11, 2006 at 3:51 am #36823

Participant

quote victor:

But IL-2 is secreted by macrophage to affect hipothalamus and increase the body’s temperature isn’t it?

Yes because hipothalamus is a centre of temperature regulation 🙂

The increased temperature or fever means to suppress the proliferation of pathogens (physical process to maintain homeostasis). When we have excessive pathogens, higher temperature we have. The proliferation of lymphocytes is due to the proliferation rate of pathogens and/or their infection rate.

January 11, 2006 at 2:18 pm #36855

Participant

Kindly explain a bit more i think i didn’t get it…:oops:

Shrei

January 12, 2006 at 4:26 am #36913

Participant

Which part do you still get no point? Try to conclude this and we will check yours 🙂

January 12, 2006 at 1:25 pm #36946

Participant

Ups..sorry..it’s not IL-2 but IL-1..:oops:

January 13, 2006 at 5:32 am #37031