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    • #17118
      gauthum
      Participant

      hello everyone
      I have a question to ask.Can gene targeting be done in human being . I mean a fully grown person.And can anyone say what would be a suitable vector for using.
      thanking you

    • #113195
      JackBean
      Participant

      what about gene therapy?

    • #113201
      jonmoulton
      Participant

      Here’s a very recent publication with a few well-known vector examples. Certainly there are other possibilities. This essay also points out some potential pitfalls.

      http://www.nature.com/nm/journal/v18/n1 … -1718.html

      I think RNA targeting is an easier way to treat many genetic conditions.

    • #113206
      gauthum
      Participant

      hello thank you for your response
      Does gene targeting has been successful in human being in much accuracy?
      can you please explain in short about cis and trans.Actually i am trying to know more about gene targeting so if you dont mind can you explain.Can retro virus can also be used as vector?

    • #113225
      jonmoulton
      Participant

      Very little work has been done in humans because of the strict regulations governing human clinical trials.

    • #113243
      gauthum
      Participant

      oh ok thank you sir.

    • #113260
      gauthum
      Participant

      sir is it possible to remove a specific gene if its locus in the dna is known by gene targeting in humans ?

    • #113261
      jonmoulton
      Participant

      It might be possible (in theory, though it would not be allowed) to remove a gene from a gamete or a single-celled zygote. However, in an adult human you would have to remove the gene from every cell, and there is no technology available to alter the DNA in so many cells at once.

    • #113298
      gauthum
      Participant

      sir but is it possible to do so in a couple of cell say a hand full of those?

    • #113303
      jonmoulton
      Participant

      Yes. Delivery efficiency to cells in adult tissue will not be 100%. There are likely to be regulatory barriers (legal restrictions). But, in principle it is possible.

    • #113307
      gauthum
      Participant

      oh ok sir thank you actually.If you dont mind can you say the ways gene targeting is done.This may be silly question but i am just doing my 12th grade so please tolerate with me sir.
      thank you for your time.

    • #113321
      jonmoulton
      Participant
    • #113369
      gauthum
      Participant

      thank you sir.

    • #113741
      gauthum
      Participant

      hello sir
      I need help.I have finished my 12th grade and i wish to become Genetic Engineer.Which course should i take in mu Under Graduation if i wanted to do Masters in Genetic.I want to do Genetic Engineering in U.S.A and i am from INDIA.Please someone help me pls pls pls.My time is running out so pls pls pls.
      Thanks for your time..:)

    • #113743
      jonmoulton
      Participant

      These come to mind.

      genetics
      organic chemistry (chemistry major’s year sequence)
      biochemistry (chemistry major’s year sequence)
      microbiology
      cell biology
      molecular biology
      recombinant DNA techniques
      microbial genetics
      molecular genetics
      plant physiology
      evolution
      instrumental chemical analysis
      statistics
      bioinformatics
      programming (for instance, C++ or a similar language)
      technical writing

      Likely you won’t find courses with exactly these names in the course catalog of your school, but try to get some exposure in these topics.

    • #113939
      gauthum
      Participant

      hello can anyone give the name of the gene involved in the production of telomerase and does in a normal cell production of telomerase is stopped???.
      thank you for your time.

    • #113952
      webtech8899
      Participant

      Thank you for making the effort to go over this, Personally i think strongly about this and love learning more about this subject. If at all possible, while you gain expertise, can you mind upgrading your site with increased information? It’s very useful for me personally.
      https://twitter.com/ScieduPress
      http://www.sciedupressblog.com

    • #114123
      gauthum
      Participant

      sure

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