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    • #6820
      gradsky
      Participant

      Hi ,

      please i want an answer for this:

      what will happen if acetylchline diffuses to the blood ?

    • #67978
      Caspase
      Participant

      Depends on how much.

      Probably nothing.

    • #67979
      gradsky
      Participant

      yes, but i want to know if a large amount diffuses for example from

      a neuromuscular junction in case of decreased release of

      acetylcholineestrase due to a disease or somewhat …

    • #68001
      sachin
      Participant

      Neurotoxic venom can do that…..

      It will block transimmision….

    • #68022
      Dr.Stein
      Participant

      If you know its function, you will see what will happen if you have too much within your blood 🙂

    • #70422
      ahm_k1
      Participant

      i THink it will be removed immediately as you can see the physician dont depend on it to resolve the problem of myesthenia gravis as it is removed but high dose affect another things away from rapid spontaneous contraction of the muscle fibers

    • #70477
      Revenged
      Participant
      quote ahm_k1:

      i THink it will be removed immediately as you can see the physician dont depend on it to resolve the problem of myesthenia gravis as it is removed but high dose affect another things away from rapid spontaneous contraction of the muscle fibers

      the treatment for myasthesia gravis is to give an cholinesterase inhibitor such as neostigme (not to give acetylcholine intravenously?!)…

      it’s action causes inhibition of acetylcholinesterase, which reduces the breakdown of acetylcholine… this means there is more acetylcholine in neuromuscular junctions and it removes the muscle weakness associated with myasthesia gravis…

      and what you are talking about is fasciculations… but you must remember that excessive stimulation of nicotinic acetylcholine receptors causes depolarisation block… this is how muscle relaxants like suxamethonium cause paralysis…

    • #70478
      Revenged
      Participant
      quote sachin:

      Neurotoxic venom can do that…..

      It will block transimmision….

      are you talking about the competitive blocker tubocurarine?…

      it was used as an arrow poison in the americas… it causes paralysis by competing with acetylcholine for nicotinic acetylcholine receptors… it is now used as a muscle relaxant during surgery…

      edit: forget about that… i see that you are talking about organophosphate poisoning now [very good example!]…

      organophosphate is an cholinesterase inhibitor… too much of it causes excessive activation of the parasympathetic nervous system (nausea, vomitting..etc.) and overactivation of the somatic nervous system (e.g. depolarising block – causing muscle paralysis)…

      here’s a good link…

      http://en.wikipedia.org/wiki/Organophos … eurotoxins

    • #70511
      ahm_k1
      Participant

      This is to Mr Revenge Hello ..I hope u r in the best condition ever.
      😮 I hoped that I havent failed to illustrate my point of view

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