IMMUNITY
- This topic has 6 replies, 3 voices, and was last updated 15 years, 10 months ago by
mayandi venkatesh.
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January 22, 2005 at 5:40 am #313
2810712
ParticipantHello, I invite U all to participate in this disscussion , please…
T helpers activate B cells and T killers. Is this activation antigen specific ?
hsg -
February 28, 2005 at 12:16 pm #19931
mayandi venkatesh
Participantquote 2810713:Hello, I invite U all to participate in this disscussion , please…
T helpers activate B cells and T killers. Is this activation antigen specific ?
hsgI want to some information about autoimmuno diseases , i never get exactly, please reply
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March 4, 2005 at 1:43 am #20017
Jelanen
ParticipantAll activation of adaptive immune response (T-cells and B-cells mainly) is antigen specific. What happens with T-cells is the naive(unactivated) T-cell (CD4–CD8 T-cell will become cytotoxic T-cells if activated) bounces around lymph nodes, constant coming in contact with professional antigen presenting cells. If the naive T-cell happens to come into contact with a antigen:MHC complex that its T-cell receptor binds, then the T-cell is activated and remains in the lymph node. In the lymph node it proliferates and differentiates into effector T-cells. CD4 T-cells can differentiate into either Th1 or Th2 T-cells. Th1 cells work with macrophages in developing a cell-mediated response while Th2 cells work with B-cells in developing an antibody-mediated immune response.
-Jelanen
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March 5, 2005 at 5:09 pm #20064
2810712
ParticipantYa, this tells that the activation of Th by lymphocytes is Ag specific , but is the activation of B cells and T killers T helpers Ag specific?
And Mayandi , I know some good immunology sites , I will tell you after my exam gets over please…
hrushikesh -
March 6, 2005 at 1:27 am #20079
Jelanen
Participantquote :All activation of adaptive immune response (T-cells and B-cells mainly) is antigen specificMissed the first sentance?
-Jelanen
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March 8, 2005 at 5:19 am #20207
2810712
ParticipantOh sorry,
but I got this question in my mind because I could not find exactly what accounts for this specificity-see Ths activate Tks and B cells simply by secreting interleukenes ; there is no any physical contact bet. Ths and Tks & Ths and B cells , as per I know, then are there several different types of ILs for sewveral Ags???please………. 😕hrushikesh
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March 13, 2005 at 12:48 pm #20419
mayandi venkatesh
Participantquote Jelanen:All activation of adaptive immune response (T-cells and B-cells mainly) is antigen specific. What happens with T-cells is the naive(unactivated) T-cell (CD4–CD8 T-cell will become cytotoxic T-cells if activated) bounces around lymph nodes, constant coming in contact with professional antigen presenting cells. If the naive T-cell happens to come into contact with a antigen:MHC complex that its T-cell receptor binds, then the T-cell is activated and remains in the lymph node. In the lymph node it proliferates and differentiates into effector T-cells. CD4 T-cells can differentiate into either Th1 or Th2 T-cells. Th1 cells work with macrophages in developing a cell-mediated response while Th2 cells work with B-cells in developing an antibody-mediated immune response.-Jelanen
Hello, guys , thank ufor ur information
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