well that depends in what reference you are talking about.That means whether solution is isotonic with respect to glucose,sodium,or any other macromolecule which may influence the osmotic properties of the cell.
If all the factors are kept "isotonic" then the net movement of any molecule will be zero.And hence there is no physical or metabolic change in the cell.
Think about a RBC in blood. Blood is the isotonic solution to RBC, but many substances are still changed through the membrane. So the key feature depends on the cell that is dead or living. If the cell is dead, only water passes through the membrane.