Is there a gene or genes that are activated at age 1 that signal to the other genes to perform gene expression appropriate for a one year old? Futhermore, is there a gene or genes that are activated at age 20 that signal to the other genes to perform gene expression appropriate for a twenty year old? Lastly, if there were a gene or genes that signals for twenty year old gene expression regulation, then if that gene were activated in an 80 year old, would the body of the 80 year old begin to exhibit the physiology of a 20 year old, thus increasing lifespan and healthspan? DE