Is there a gene or genes that are activated at age 1 that signal to the other genes to perform gene expression appropriate for a one year old? Futhermore, is there a gene or genes that are activated at age 20 that signal to the other genes to perform gene expression appropriate for a twenty year old? Lastly, if there were a gene or genes that signals for twenty year old gene expression regulation, then if that gene were activated in an 80 year old, would the body of the 80 year old begin to exhibit the physiology of a 20 year old, thus increasing lifespan and healthspan? DE
Is there a 10 base pair alteration to the human genome that can double the maximal human lifespan to 240 years? By 10 base pair alteration I mean the alteration of 10 base pairs to 10 other base pairs. Additionally, is there a 20 base pair alteration to the human genome that can double the maximal human lifespan to 240 years? What will end up being the minimal number of base pair alterations necessary to double the maximal human life span? DE
One good method would be to compare the genetic sequence of billions of people and the ages of those people and compare them to see which genetic sequences are prevalent in longer lived people. Once the sequences are determined, then gene edit the desired sequences into a patient’s DNA. DE
Aging is not only a question of DNA sequence. We live thanks to oxygen and oxygen has toxic consequences, because of free radicals, for our cells. Studies have been performed to look for specific genes expressed in people who reach 100 years. Probably you can find the results on internet. It seems to me that the results are not so clear and that there was some genes involved in oxydative metabolism. To answer the question of genes at year 1, in the development genes can be expressed shortly at a given time and then are no longer expressed.