Lactate is converted to pyruvate (by NAD+ dependent lactate dehydrogenase). Pyruvate is converted to Acetyl CoA and then, this pass to Krebs’ Cycle.

The aerobic catabolization of lactate generates the formation of 17 ATP.

can u show us the calculation, please..

You’re welcome ;).

look in the table in metabolism: lactate is converted to pyruvate by lactate dehydrogenase and yield 1 NADH (2,5 ATP)

then pyruvate is metabolized in de krebscycle yielding:
4 NADH = 10 ATP
1 FADH2 = 1,5 ATP
1 GTP = 1 ATP

total = 12,5 ATP + 2,5 ATP = 15 ATP

Is their any way to increase or decrease the rate of metabolisme?

15 is the correct answer, i don’t know where the 2 ATP from enzyme came from.

Hey, thanks for the correction! 😉

Sorry, I have read again my post answering kabuto’s question and I’ve seen that I wrote: ’17 ATP’. I wanted to mean ’18 ATP’. I didn’t see the mistake before.

The explanation of my answer is because I did the calculations basing me in the next equivalences:

1 NADH = 3 ATP.
1 FADH2 = 2 ATP.
1 GTP = 1 ATP.

When lactate is converted to pyruvate, one NAD+ is reduced to NADH. So the value in ATP molecules (taking in account the equivalences shown at the top of this paragraph) is 3 ATP.

So my point of view would be:

1. Lactate —> Pyruvate [1 NADH = 3 ATP]
2. Pyruvate —> Acetyl CoA [1 NADH = 3 ATP]
3. Krebs’ cycle [3 NADH = 9 ATP, 1 FADH2 = 2 ATP and 1 GTP = 1 ATP]

In conclusion:

3 ATP + 3 ATP + 9 ATP + 2 ATP + 1 ATP = 18 ATP

The true values in ATP molecules of NADH and FADH2 are 2.5 and 1.5 respectively. But for questions of a better teaching or I don’t know, many people round up the values to 3 and 2 respectively. For that I based my explanation on those values.

Thanks for the correction again ;). See you! 😉

But don’t forget that there are TWO pyruvates that enter into the cycle for each glucose molecule. So do you double the number of ATP’s for glucose or are you looking for just ONE pyruvate?

Eolian

My explanation is for one pyruvate (1 malate —> 1 pyruvate). But thanks Eolian for your statement.

no, because 1 lactate will yield 1 pyruvate. It’s not glucose metabolism 😉