Biology Forum Molecular Biology Pericentromere specific probes for FISH

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      Hi all,

      Im trying to do a FISH on DNA combing for pericentromeric regions.

      As you may know, the human centromere is actually separated into two distinct regions: 1) centromeric region – which is involved in kinetochore binding 2) pericentromere region – a heterochromatic region which is involved in sister chromatid binding.

      Im looking for pericentromere specific probes which do not overlap with any other region (centromeric or non centromeric).

      Does anyone have a clue whether this kind of probes/BAC/HAC/anything else exist? if so – a link would be great!

      Thank you!


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