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    • #971
      zami’87.
      Participant

      I have some questions about chaperonins and protein folding…
      1.How do chaperonins help folding the polypeptide chain(know about hydrogen bonds but mechanism…)? like enzyme?What’s their origin? And did “first cell” contain genes for them?What if there would be a mutation and and some chaperonin would be nonfunctional? Would it be lethal?
      How do polypeptide chains form protein with quaternary structure(are there also some helpers -exept chap.)?
      Maybe sounded stupid but you can easily lost in details 😳
      Thanks in advance!

    • #23471
      zami’87.
      Participant

      I did little search and I think that I understand mechanism now but still I didn’t find answers to most of my questions
      What’s their origin? And did “first cell” contain genes for them?
      What if there would be a mutation and and some chaperonin would be nonfunctional? Would it be lethal?
      now I read that ribosomes in prokaryotes don’t have chaperonins function so it would be lethal for prokaryotes but I’m not sure for eukaryotes cause their ribosomes have that function …so does that mean that most of mutations in genes for chaperones wouldn’t be lethal?
      And I read that mutation for hsp90 would be lethal in early embrionic stage….
      Now do you know some diseases related to non functional chaperones? And if someone has idea about my previous questions, just an idea …..THANKS!!!!
      ps most informations from http://www.chaperone.sote.hu/Examples.html
      🙁

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