- February 22, 2011 at 1:54 am #14544
Hey guys, so I’m given a long strand of protein (shown below). It is predicted to be nuclear localized but how can I know that it’s nuclear localized just by looking at its primary sequence? I mean we can probably do some protein tagging to localize it experimentally but I have no idea how the prediction part comes about. Thanks in advance for any help.
- February 22, 2011 at 3:13 am #103583
- February 22, 2011 at 3:52 am #103584
I have used predictor tools but I want to know how to predict localization just by looking at the primary sequence.
- February 22, 2011 at 6:35 pm #103590JackBeanParticipant
but that’s what the predictors do, they look on the primary structure and look for specific patterns, which could mean localisation into any organelle
- February 23, 2011 at 12:14 am #103598
does this have something to do with locating a part of the main sequence called the nuclear localization signal with indicates nuclear localization? and if so what is the sequence of the nuclear localization signal?
- February 23, 2011 at 9:13 am #103604
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