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    • #14985

      I have come across these terms: homodimer, heteromer, hexamer,etc. I don’t quite understand what they mean. I would appreciate it if you could explain me in detail the significance of these terms. You may also do by just posting a link so that I’ll read it myself. I couldn’t find it online the relevant data related to these terms.

      I also want to know what happens when proteins are treated with Mercaptoethanol, urea, etc.
      Thank you.

    • #104981

      Basically learn greek.
      Homo: same
      Hetero: different
      di: 2
      hexa: 6
      Mer (actually not sure if the root is greek for that one): unit
      Homo di mer: same 2 units is aprotein made of 2 identical subunits
      Hetero di mer: 2 different units

    • #104982

      So with "-mer" you mean a subunit? That is a polypeptide?
      Also, what is the difference between: protein domain, polypeptide, subunit.
      I guess all the three words mean the same.

    • #104985

      Protein domain: A portion of a protein usually defined by a specific function (zinc finger or some such). There might be more than one domain in one polypeptide.
      Polypeptide: a large chain of amino acids, but not a protein.
      Subunit: usually one of the many polypeptide composing a protein

    • #104991

      In case of protein with alcohol it will denature the side chains affecting hydrogen bondings while in case of protein with urea will affect covalent bonds and urea is a powerful denaturant than alcohol

    • #105008

      1) are you sure, that urea will disrupt covalent bonds? I highly doubt, since such denatured proteins can be renatured after dialysis.
      2) how is that related to the topic? 🙄

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