Biology Forum › Genetics › Question about CJD
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- March 31, 2011 at 5:24 am #14752
BrodoParticipantI would just like to confirm my understanding of CJD (creutzfeldt Jakob Disease)
My notes say that the PrPc protein is converted by some unknown protein x into PrP*
Would this protein x be the prion?Also, the effect of this conversion is that the PrP* will use a PrPsc protein as a template to convert PrP* into another PrPsc. Where did this initial PrPsc protein come from?
Thank you
- March 31, 2011 at 3:21 pm #104235DarbyParticipant
The assumption is that the protein is maybe from a mutated code, with a change that a) makes it fold up differently, and b) produces a form that can reconform the "regular" version into something like it.
- March 31, 2011 at 11:10 pm #104244BrodoParticipant
Okay, thanks.
But is protein x a prion? - April 1, 2011 at 3:06 am #104251canalonParticipant
generally yes.
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