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      maimaiti2008
      Participant

      Hi,

      We have learnt that type II topoisomerase can relax the positive supercoil by cutting off two strands of one DNA molecule. However, in contrast to type I topoisomerase, type II topoisomerase does not reduce the number of twist. So after type II topoismerase functions, only the number of writhe decreases. I was wondering if the DNA molecule will form supercoil again because the density of twist is still very high?

      Thanks!

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