Regulatory elements inside introns

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    • #16408
      roniadam
      Participant

      Hi

      I am wondering if intron have regulatory elements other than splicing recognition signals (Donor, Acceptor and branch point sites). because I have found a mutation in the middle of the intron of my gene and noticed that the patient has some phenotypic resulted from this mutation. So is there any regulatory elements can be found in the introns of some genes? If yes? what type of regulatory elements because I do think that regulatory elements should be found in the promoter region to deliver the expression correctly…!!!

    • #110825
      jonmoulton
      Participant

      Try a search using the key phrase "intronic splice silencers". Alternative splicing is directed by proteins binding to RNA, often at regions distant from the splice junctions.

    • #110829
      AstraSequi
      Participant

      Gene promoters, binding sites for regulatory proteins/microRNAs, etc can also be within introns.

    • #110838
      JackBean
      Participant

      microRNA can originate from the intron or enhancer site could be there

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