Biology Forum Media PDF & Doc Files The Molecular Biology of the Cell, 4th Edition, online FREE!

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    • #1956

      The entire Molecular Biology of the Cell, 4th Edition, which is a completely fantastic book and the standard reference for the subject, is online free at Pubmed!

      The only thing it lacks is a convenient index. So I made one.
      The online version also has ALL the pictures and figures.

      Since I can’t add the HTML as an attachment, I pasted it into this message.

      Direct links to NCBI’s Molecular Biology of the Cell have been disabled due NCBI request, however you can still preview some chapters directly on NCBI

      Have fun!


      A Note to the Reader

      I. Introduction to the Cell

      1. Cells and Genomes

      The Universal Features of Cells on Earth

      The Diversity of Genomes and the Tree of Life

      Genetic Information in Eucaryotes


      2. Cell Chemistry and Biosynthesis

      The Chemical Components of a Cell

      Catalysis and the Use of Energy by Cells

      How Cells Obtain Energy from Food


      3. Proteins

      The Shape and Structure of Proteins

      Protein Function


      II. Basic Genetic Mechanisms

      4. DNA and Chromosomes

      The Structure and Function of DNA

      Chromosomal DNA and Its Packaging in the Chromatin Fiber

      The Global Structure of Chromosomes


      5. DNA Replication, Repair, and Recombination

      The Maintenance of DNA Sequences

      DNA Replication Mechanisms

      The Initiation and Completion of DNA Replication in Chromosomes

      DNA Repair

      General Recombination

      Site-Specific Recombination


      6. How Cells Read the Genome: From DNA to Protein

      From DNA to RNA

      From RNA to Protein

      The RNA World and the Origins of Life


      7. Control of Gene Expression

      An Overview of Gene Control

      DNA-Binding Motifs in Gene Regulatory Proteins

      How Genetic Switches Work

      The Molecular Genetic Mechanisms That Create Specialized Cell Types

      Posttranscriptional Controls

      How Genomes Evolve


      III. Methods

      8. Manipulating Proteins, DNA, and RNA

      Isolating Cells and Growing Them in Culture

      Fractionation of Cells

      Isolating, Cloning, and Sequencing DNA

      Analyzing Protein Structure and Function

      Studying Gene Expression and Function


      9. Visualizing Cells

      Looking at the Structure of Cells in the Microscope

      Visualizing Molecules in Living Cells


      IV. Internal Organization of the Cell

      10. Membrane Structure

      The Lipid Bilayer

      Membrane Proteins


      11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes

      Principles of Membrane Transport

      Carrier Proteins and Active Membrane Transport

      Ion Channels and the Electrical Properties of Membranes


      12. Intracellular Compartments and Protein Sorting

      The Compartmentalization of Cells

      The Transport of Molecules between the Nucleus and the Cytosol

      The Transport of Proteins into Mitochondria and Chloroplasts


      The Endoplasmic Reticulum


      13. Intracellular Vesicular Traffic

      The Molecular Mechanisms of Membrane Transport and the Maintenance of Compartmental Diversity

      Transport from the ER through the Golgi Apparatus

      Transport from the <i>Trans</i> Golgi Network to Lysosomes

      Transport into the Cell from the Plasma Membrane: Endocytosis

      Transport from the <i>Trans</i> Golgi Network to the Cell Exterior: Exocytosis


      14. Energy Conversion: Mitochondria and Chloroplasts

      The Mitochondrion

      Electron-Transport Chains and Their Proton Pumps

      Chloroplasts and Photosynthesis

      The Genetic Systems of Mitochondria and Plastids

      The Evolution of Electron-Transport Chains


      15. Cell Communication

      General Principles of Cell Communication

      Signaling through G-Protein-Linked Cell-Surface Receptors

      Signaling through Enzyme-Linked Cell-Surface Receptors

      Signaling Pathways That Depend on Regulated Proteolysis

      Signaling in Plants


      16. The Cytoskeleton

      The Self-Assembly and Dynamic Structure of Cytoskeletal Filaments

      How Cells Regulate Their Cytoskeletal Filaments

      Molecular Motors

      The Cytoskeleton and Cell Behavior


      17. The Cell Cycle and Programmed Cell Death

      An Overview of the Cell Cycle

      Components of the Cell-Cycle Control System

      Intracellular Control of Cell-Cycle Events

      Programmed Cell Death (Apoptosis)

      Extracellular Control of Cell Division, Cell Growth, and Apoptosis


      18. The Mechanics of Cell Division

      An Overview of M Phase




      V. Cells in Their Social Context

      19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix

      Cell Junctions

      Cell-Cell Adhesion

      The Extracellular Matrix of Animals


      The Plant Cell Wall


      20. Germ Cells and Fertilization

      The Benefits of Sex


      Primordial Germ Cells and Sex Determination in Mammals





      21. Development of Multicellular Organisms

      Universal Mechanisms of Animal Development

      Caenorhabditis Elegans: Development from the Perspective of the Individual Cell

      Drosophila and the Molecular Genetics of Pattern Formation: Genesis of the Body Plan

      Homeotic Selector Genes and the Patterning of the Anteroposterior Axis

      Organogenesis and the Patterning of Appendages

      Cell Movements and the Shaping of the Vertebrate Body

      The Mouse

      Neural Development

      Plant Development


      22. Histology: The Lives and Deaths of Cells in Tissues

      Epidermis and Its Renewal by Stem Cells

      Sensory Epithelia

      The Airways and the Gut

      Blood Vessels and Endothelial Cells

      Renewal by Multipotent Stem Cells: Blood Cell Formation

      Genesis, Modulation, and Regeneration of Skeletal Muscle

      Fibroblasts and Their Transformations: The Connective-Tissue Cell Family

      Stem-Cell Engineering


      23. Cancer

      Cancer as a Microevolutionary Process

      The Preventable Causes of Cancer

      Finding the Cancer-Critical Genes

      The Molecular Basis of Cancer-Cell Behavior

      Cancer Treatment: Present and Future


      24. The Adaptive Immune System

      Lymphocytes and the Cellular Basis of Adaptive Immunity

      B Cells and Antibodies

      The Generation of Antibody Diversity

      T Cells and MHC Proteins

      Helper T Cells and Lymphocyte Activation


      25. Pathogens, Infection, and Innate Immunity

      Introduction to Pathogens

      Cell Biology of Infection

      Innate Immunity



    • #29915

      Alberts book, 4th edition, online, for free? I deffinetly owe you one. This book is gold if you want a medal at IBO

    • #29917

      Damn…no wonder the rest of the world is so far ahead of americans in science. There’s only one chapter on plants here, but our bio teacher is spending 9 weeks(probably more, he tells us we’re moving at a snail’s turtle pace) teaching us about plant development….

    • #29922
      quote MrMistery:

      Alberts book, 4th edition, online, for free? I deffinetly owe you one. This book is gold if you want a medal at IBO

      Then you should definitely browse the bookshelf section of Medline where you will find free of charge many great books, and not only the Alberts.



    • #29942

      that is super great! If i only had the time to read them all… 😥 😥

      Well, your system is based on a need to know principle. Since not everyone there will become a biologist they only teach what is necessary for everyone to know. If you want to study more go to the store, buy books and read them. that’s what i do. So far, i have 3 shelves full of bio books, not including campbell and alberts which are on my desk, at the place of honor 😀

    • #31878

      Please note:

      Reproduction of books material is unethical and strictly prohibited. There is a disclaimer on the Molecualr Biology of the Cell pages explaining this:


      This is also discussed int he FAQ http://www.ncbi.nlm.nih.gov/entrez/quer … okfaq.html

      The BOOKS online are copyrighted by the authors and / or publishers.



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