Traslocation

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    • #15787
      Depo
      Participant

      I know that a traslocation usually appears in the meiotic process and could cause the loss of gene function if the breaking point is inside the gene,or could create new gene product by fusion.

      Well,my question is: could a transocation appear also in the nucleus as a fusion between two genes,while they are near the same transcription factory due to the RNA transcription?

      And what could cause this mutation?

      Perhaps my english isn’t very correct,as I’m an italian student who is learning abroad 😀

    • #108560
      JackBean
      Participant

      Can you explain more, what exactly you mean? Maybe with some simple picture.

    • #108564
      Depo
      Participant

      Surfing the web, I found an interesting picture that I’ve posted as attachment.
      The image shows the cellular organization of chromosomes in the nucleus; you can observe that in the interchromatin space there is a transcription factory (in the picture: RNA transcripts) ,while around this region there are more than one active locus( of different chromosomes).Then,since the chromosomes are so close ,could happen that a traslocation appear between these active loci ?


      Attachments:

    • #108573
      JackBean
      Participant

      I think that could happen. However, viability of such cell would be questionable.

    • #108643
      Depo
      Participant

      This research should be interesting ,if you want to read it : http://www.sciencedirect.com/science/article/pii/S0092867407001262

      In the article there is also a paragraph about traslocation,what do you think?

    • #108644
      jonmoulton
      Participant

      New studies – I think you’ll find these right on topic.
      http://www.nature.com/nbt/journal/v29/n … .2030.html
      http://www.nature.com/nbt/journal/v29/n … .2049.html

    • #108667
      Depo
      Participant

      thank for posting these researches,I’ve found them satisfying

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