[Depo]

I know that a traslocation usually appears in the meiotic process and could cause the loss of gene function if the breaking point is inside the gene,or could create new gene product by fusion.

Well,my question is: could a transocation appear also in the nucleus as a fusion between two genes,while they are near the same transcription factory due to the RNA transcription?

And what could cause this mutation?

Perhaps my english isn’t very correct,as I’m an italian student who is learning abroad 😀

[JackBean]

Can you explain more, what exactly you mean? Maybe with some simple picture.

[Depo]

Surfing the web, I found an interesting picture that I’ve posted as attachment.
The image shows the cellular organization of chromosomes in the nucleus; you can observe that in the interchromatin space there is a transcription factory (in the picture: RNA transcripts) ,while around this region there are more than one active locus( of different chromosomes).Then,since the chromosomes are so close ,could happen that a traslocation appear between these active loci ?

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Attachments:

[JackBean]

I think that could happen. However, viability of such cell would be questionable.

[Depo]

This research should be interesting ,if you want to read it : http://www.sciencedirect.com/science/article/pii/S0092867407001262

In the article there is also a paragraph about traslocation,what do you think?

[jonmoulton]

New studies – I think you’ll find these right on topic.
http://www.nature.com/nbt/journal/v29/n … .2030.html
http://www.nature.com/nbt/journal/v29/n … .2049.html

[Depo]

thank for posting these researches,I’ve found them satisfying

[Author]

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