Biology Forum › Genetics › Traslocation
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December 3, 2011 at 8:13 pm #15787
Depo
ParticipantI know that a traslocation usually appears in the meiotic process and could cause the loss of gene function if the breaking point is inside the gene,or could create new gene product by fusion.
Well,my question is: could a transocation appear also in the nucleus as a fusion between two genes,while they are near the same transcription factory due to the RNA transcription?
And what could cause this mutation?
Perhaps my english isn’t very correct,as I’m an italian student who is learning abroad 😀
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December 3, 2011 at 8:36 pm #108560
JackBean
ParticipantCan you explain more, what exactly you mean? Maybe with some simple picture.
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December 4, 2011 at 11:26 am #108564
Depo
ParticipantSurfing the web, I found an interesting picture that I’ve posted as attachment.
The image shows the cellular organization of chromosomes in the nucleus; you can observe that in the interchromatin space there is a transcription factory (in the picture: RNA transcripts) ,while around this region there are more than one active locus( of different chromosomes).Then,since the chromosomes are so close ,could happen that a traslocation appear between these active loci ? -
December 5, 2011 at 8:01 am #108573
JackBean
ParticipantI think that could happen. However, viability of such cell would be questionable.
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December 8, 2011 at 6:16 pm #108643
Depo
ParticipantThis research should be interesting ,if you want to read it : http://www.sciencedirect.com/science/article/pii/S0092867407001262
In the article there is also a paragraph about traslocation,what do you think?
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December 8, 2011 at 9:19 pm #108644
jonmoulton
ParticipantNew studies – I think you’ll find these right on topic.
http://www.nature.com/nbt/journal/v29/n … .2030.html
http://www.nature.com/nbt/journal/v29/n … .2049.html -
December 10, 2011 at 1:33 pm #108667
Depo
Participantthank for posting these researches,I’ve found them satisfying
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