Viewing 5 reply threads
  • Author
    Posts
    • #15357
      sometime
      Participant

      Dear all, I am a new member…I am desperately trying to find the PDF file with full text of the following article:

      First-trimester genetic diagnosis: a series of six cases
      South dacoda medicine 2010, Mar 63(3): 83-5
      PMID 20301870
      Stein QP et all

      and any other article that can hepl to understand if after an ultrasound screen with biochemical marckers unusual and normal NT ( and combined risk normal) it is adviceble to go through amniocentesis or not!!

      The university of the city where I live has no access to this review unfortunately!

    • #106251
      JackBean
      Participant

      I’m little afraid that for articvle from South dacoda medicine you will have to contact the authors 😆 Our system doesn’t even know that journal 😆

    • #106261
      sometime
      Participant

      WEll…I looked in pubmed but there is no e-mail address of the corresponding author unfortunately….the following is all it appears:

      First-trimester genetic diagnosis: a series of six cases
      S D Med. 2010 Mar;63(3):83-5.
      First-trimester genetic diagnosis: a series of six cases.
      Stein QP, Flanagan JD, Knutsen-Larson S, Van Eerden P.
      Source

      Sanford Women’s Health & Sanford Children’s Specialty Clinic, Sioux Falls, SD, USA.
      Abstract

      A first-trimester screen consists of a nuchal translucency (NT) ultrasound measurement as well as maternal serum testing for pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (hCG). An increased nuchal translucency (NT) thickness at 11 to 14 weeks gestational age is a common finding for Down syndrome, Trisomy 18 and cardiac defects. We present a series of six patients, four with NT measurements greater than the 95th centile, and two additional cases where the NT was normal, but maternal serum biochemical markers were unusual. All six of these cases had a chromosome anomaly or another genetic condition: Noonan syndrome, triploidy, Down syndrome, Trisomy 18, Turner syndrome and a rare chromosome abnormality known as Ring 18-Monosomy 18. Our series underlines the fact that it is important to explore other genetic and chromosome abnormalities, in addition to Down syndrome and Trisomy 18, when there is an abnormality on a first-trimester screen.

      PMID:
      20301870
      [PubMed – indexed for MEDLINE]

      ANY OTHER IDEA??? :-((!!

    • #106264
      JackBean
      Participant

      this is page of the clinic, where they (at least the first one) work http://www.sanfordhealth.org/Contact However, I cannot find contact directly to him, so try to write to the clinic for contact to the doctor and then…

    • #106265
      sometime
      Participant

      thank you millions!!! 😀 ! Your suggestion helped me to find the address of Professor Stein and wrote him an e-mail for paper request…hoping that he’ll reply!

    • #116316
      anitapaul001
      Participant

      Can anyone please suggest, which surfactants and chelating agents can be used as permeation enhancer in case of low bioavalability?
      http://pharmawiki.in/

Viewing 5 reply threads
  • You must be logged in to reply to this topic.