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    • #16223
      softblackstars
      Participant

      or it is called " polycomb repressor"?

    • #110163
      canalon
      Participant

      From: http://www.plosone.org/article/info:doi … ne.0002704
      We have:

      quote :

      Background

      The Polycomb Repressive Complex 2 (PRC2) functions as a transcriptional repressor through a mechanism that involves methylation of Histone H3 at lysine 27. The PRC2 complex activity is essential for cellular proliferation, development, and cell fate decisions. PRC2 target genes include important regulators of development and proliferation as well as tumor suppressor genes. Consistent with this, the activity of several Polycomb group (PcG) proteins is deregulated in human cancer suggesting an important role for PcGs in tumor development. Whereas the downstream functions of PcGs are well characterized, the mechanisms of their recruitment to target genes and the regulation of their activity are not fully understood.

      Any particular detail?

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