Biology Forum › Community › General Discussion › Anisotropy – Help!
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- October 2, 2005 at 7:49 am #2042paperclipParticipant
The theoretical maxium for kcat/Km is about 108 to 109 (mol/L)-1s-1. At this point, every collision of the enzyme with its substrate will result in catalysis. Some enzymes, such as fumarase, actually approach this limit.
My questions are:
1) How do enzymes manage to grab substrates from the solution they are in. Is there a harpoon mechanism present?
2)How can fumarase have such a high enzyme efficiency, it seems that steric factors are neglected or is an exageration that EVERY COLLISION will result in catalysis. Please explain why.
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