Cell Bio

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    • #15495
      spacecowboi
      Participant

      Why (in detail please) in the carboxypeptidase mechanism, the weak bonds between an enzyme and a substrate will stretch the peptide bond of the substrate which lowers the bond energy?

      I just want to know why in detail this happens… Thank you.

    • #106770
      JackBean
      Participant

      that’s a common mechanism in enzymes, not only in carboxypeptidase. However, the point is, there are several of these "weak" bonds and their sum is strong enough to stretch the peptide causing to be better to hydrolyse.

    • #106819
      spacecowboi
      Participant

      I see that clarifies it. Also, I know it is Tyrosine that attacks carboxypeptidases C-terminus, although how is Tyrosine capable of doing so?

    • #106941
      JackBean
      Participant

      My guess would be the hydroxyl group, but I would need to see some article about this matter to explain it more deeply.

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