Cell Bio - Biology Forum

last updated by

JackBean 13 years, 1 month ago

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- October 10, 2011 at 5:21 am #15495
  spacecowboi
  Participant
  Why (in detail please) in the carboxypeptidase mechanism, the weak bonds between an enzyme and a substrate will stretch the peptide bond of the substrate which lowers the bond energy?
  I just want to know why in detail this happens… Thank you.
- October 10, 2011 at 6:16 am #106770
  JackBean
  Participant
  that’s a common mechanism in enzymes, not only in carboxypeptidase. However, the point is, there are several of these "weak" bonds and their sum is strong enough to stretch the peptide causing to be better to hydrolyse.
- October 11, 2011 at 7:29 pm #106819
  spacecowboi
  Participant
  I see that clarifies it. Also, I know it is Tyrosine that attacks carboxypeptidases C-terminus, although how is Tyrosine capable of doing so?
- October 17, 2011 at 6:32 am #106941
  JackBean
  Participant
  My guess would be the hydroxyl group, but I would need to see some article about this matter to explain it more deeply.
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