This what I can remember, I hope it helps. Hmm you know that antibody bind to antigens right. But did you know you can make antibodies attack antibodies too. idiotypes are antibodies’s varible regions (their own antigen recognition site), which are being attacked by other antibodies. So basically antibodies’ variable region are themselves being used as antigen sites. Maybe I can rephrase it a little.
I did not look in the textbook for this one because I constantly use antibodies for blotting experiments, and idiotype was just something that came to me.
