Biology Forum › Cell Biology › Kinases
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- September 22, 2012 at 9:57 am #16859
x555ParticipantI’m thinking about this question regarding kinases and I’m not sure if I have the right answer. What do kinases use as an energy source? Is the answer ATP?
- September 24, 2012 at 3:13 pm #112443jonmoultonParticipant
You can think of an ATP as an ADP and a phosphate bound together. It is the bond between the ADP moiety and the phosphate moiety that is the highest-energy bond in the molecule. If the terminal phosphate of ATP is transferred to a protein (releasing free ADP) then the system is in a lower-energy state that was the initial ATP and un-phosphorylated protein. That release of energy helps drive the reaction to the ADP & phosphoprotein side.
Not every kinase will use ATP as a substrate. Other high-energy phosphates are available in cells and there are many kinases.
- September 25, 2012 at 9:18 am #112445x555Participant
Thank you very much!
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