Biology Forum Molecular Biology "salt of DNA"

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    • #9699
      steve9191
      Participant
      quote Watson and Crick:

      “We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.).”

      As a non-scientific writer, when I ran across this quote I was a little confused. I know that DNA is an acid, I just can’t figure out how salt got into the picture. Through Google searches, I tried to get answers to my questions about this quote, but have been largely unsuccessful. If anybody here would be kind enough to help out a scientific "outsider", I sure would be grateful.

      Is it accurate to say that DNA is a salt, or is it more accurate to say that DNA contains/produces salt? Does salt, somehow, have an impact on the functioning of DNA?

      Thanks, Steve

    • #84340
      blcr11
      Participant

      The phosphates of the DNA polymer are negatively charged. They will bind a cation as a counterion to achieve electroneutrality–usually Na+ or K+. That makes the polymer a "salt" of [Na+]x[DNA-].

    • #84341
      steve9191
      Participant

      Super. Thanks!

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