To shear it in small and relatively constant fragment before say cloning. You can also use a fine needle or a nebulizer. it is cheaper and less sequence specific than restriction enzyme, with break point that should be entirely random, which should give a better chance to get complete coverage for sequence, or to avoid cutting in the middle of your gene of interest.
Thank you for all replies. Unfortunately I wasn’t able to find as many protocols about sonication as I want:(
If anyone of you has knowledge or links about it I would really appreciate it.
