Biology Forum › Molecular Biology › Transcription
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- December 30, 2010 at 9:57 pm #14309
dkavParticipantAt the end of transcription, what guides the movement of RNA out of the nucleus in eukaryotic cells, or the movement of any molecules? Is it because of their affinities for other molecules? And where do affinities come from? Thanks.
- March 6, 2011 at 12:35 am #103750BatleeParticipant
It’s the NES Nuclear Export Signal. A short amino acid sequence of 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex.
- March 6, 2011 at 10:09 am #103753JackBeanParticipant
well, he was asking for mRNA, which has no NES 😉
- March 6, 2011 at 11:48 am #103756DRT23Participant
I know that exportin proteins guides miRNAs out of nucleus and probably similar proteins work for mRNAs. If so, this exportin proteins should have NES as Batlee says.
- March 12, 2011 at 10:51 am #103872BatleeParticipant
"RNA are composed of nucleotides, and thus, lack the nuclear export signal to move out of the nucleus. As a result, most forms of RNA will bind to a protein molecule to form a ribonucleoprotein complex to be exported from the nucleus."
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