Hello,

On a recent test, this question appeared and I was really sure I had the right answer… Only I didn’t. Now I really don’t get the question and I would like to ask you to help me! This is the question:

The growth factor Superchick stimulates proliferation of cultured chicken cells. The receptor that binds Superchick is a receptor tyrosine kinase, and many tumor cell lines have mutations in the gene that encodes this receptor.
Which of the following types of mutations would be expected to induce uncontrolled cell proliferation? (2 points):
a) A mutation that prevents localization of the receptor to the plasma membrane.
b) A mutation that prevents dimerization of the receptor.
c) A mutation that destroys the kinase activity of the receptor.
d) A mutation that prevents recognition of the receptor by phosphatases.
e) A mutation that prevents ligand binding.

I won’t post my answer and explanation yet, so you can form your own answer and maybe help me understand! 🙂
Thank you!