Biology Forum › Cell Biology › Which metalloenzyme is most found in mitochondria?
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- December 24, 2009 at 3:55 am #12517ATPenergyParticipant
Which metalloenzyme is most found in mitochondria?
A.Cu metalloenzyme
B.Mg metalloenzyme
C.Mn metalloenzyme
D.Cd metalloenzyme
E.Zn metalloenzyme - December 24, 2009 at 11:43 am #96238JackBeanParticipant
Cd for sure not. Also Zn, Mn and Cu are probably minor, so Mg will be the most found one 😉
- December 24, 2009 at 10:36 pm #96243MrMisteryParticipant
It’s actually Fe. But also Cu: cytochrome oxidase has a Fe-Cu bimetallic center. I don’t know of any mitochondrial enzymes with Mg, Cd or Zn.
- December 24, 2009 at 11:20 pm #96245JackBeanParticipant
Mg is in any enzyme binding phosphate in any form. But they are probably not located in mitochondrion…
I was looking to UniProt, and althrought there are not all proteins, iron and cuprum seems to lead 🙂
http://www.uniprot.org/uniprot/?query=o … d#9993,479
(for me 🙁 ) - December 28, 2009 at 7:51 am #96288MrMisteryParticipant
well yeah, DNA polymerases and RNA polymerases have Mg ions, but in the mitochondria the respiratory enzymes outnumber all other proteins by far. So yeah, Fe probably leads as it is found in both those Fe-S centers of Riske proteins but also in the Fe-Cu centers. Cu are only in the Fe-Cu centers. No idea why the person didn’t include Fe in the answer choices.
- December 28, 2009 at 7:53 am #96289MrMisteryParticipant
scratch that, the ATP synthase also has Mg. I still think there is more of the Cu ones though. that uniprot link doesn’t have Mg unfortunately
- December 29, 2009 at 6:29 am #96307qqsveryParticipant
you guys were all wrong!Mn diversity cell line panel is the most~the Mn-SOD is the most in mitochondrion!
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